Study of the effect of dose-rate on radiation-induced damage to human erythrocytes

摘要

Human erythrocytes suspended in an isotonic Na-phosphate buffer,pH 7.4 (hematocrit of 2%) were irradiated with gamma-rays at three dose-rates of 66.7,36.7,25 Gy min~(-1) in order to investigate the influence of the dose-rate on radiation-induced membrane damage,hemoglobin oxidation and loss of reduced glutathione.The obtained results showed that such processes as erythrocyte hemolysis,lipid and protein destruction depend on the radiation dose-rate.The parameter values describing these processes showed an inverse dose-rate effect.