Absence of germline mutations in genes within the MAP kinase pathway in familial non-medullary thyroid cancer.

摘要

Follicular cell-originated non-medullary thyroid cancer (NMTC) is the most common thyroid cancer, accounting for more than 90% of all thyroid malignancies.There is a widely recognized distinct familial form of NMTC (FNMTC) which is characterized by the occurrence of this cancer in two or more first-degree family members, widi a tendency to have multifocality, early onset, increased recurrence, and higher degree of aggressiveness. FNMTC accounts for approximately 5% of non-medullary thyroid cancers. Histologically, 90% of FNMTC are papillary thyroid cancer (PTC) and the remainder is follicular thyroid cancer (FTC), including Hurthle-cell variant. Linkage analysis on kindreds from different families with FNMTC mapped the susceptible locus to several chromosomes, but no specific susceptible gene has been identified.