Preparation and Properties of ~(68)Ga Complexes with RGD Peptide Derivatives

V. B. Bubenshchikov; A. Ya. Maruk; A. B. Bruskin; G. E. Kodina

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Preparation and Properties of ~(68)Ga Complexes with RGD Peptide Derivatives

机译：具有RGD肽衍生物的〜（68）Ga配合物的制备和性质

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摘要

Conditions allowing preparation of ~(68)Ga complexes with RGD peptide derivatives with no less than 95% radiochemical purity were determined. The complexes are stable in blood plasma for the time sufficient for performing a diagnostic investigation.

机译：确定了允许制备具有RGD肽衍生物的〜（68）Ga配合物的条件，其中RGD肽衍生物的放射化学纯度不低于95％。该复合物在血浆中稳定足以进行诊断研究的时间。

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《Radiochemistry 》 |2016年第5期| 共7页
作者
V. B. Bubenshchikov; A. Ya. Maruk; A. B. Bruskin; G. E. Kodina;
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原文格式 PDF
正文语种 eng
中图分类计量学 ;
关键词
gallium-68; RGD; complexation; chelating agents; radiopharmaceuticals;

机译：镓68;RGD;络合物;螯合剂;放射性药物;

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专利

1. Preparation and Properties of ~(68)Ga Complexes with RGD Peptide Derivatives [J] . V. B. Bubenshchikov, A. Ya. Maruk, A. B. Bruskin, Radiochemistry . 2016 ,第5期

机译：具有RGD肽衍生物的〜（68）Ga配合物的制备和性质
2. The practicality of nanoceria-PAN-based 68Ge/68Ga generator toward preparation of 68Ga-labeled cyclic RGD dimer as a potential PET radiotracer for tumor imaging [J] . ChakrabortyS., ChakravartyR., SarmaH.D., Cancer biotherapy and radiopharmaceuticals . 2013 ,第1期

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3. [Ga-68]FSC-(RGD)(3) a trimeric RGD peptide for imaging alpha(v)beta(3) integrin expression based on a novel siderophore derived chelating scaffold-synthesis and evaluation [J] . Knetsch Peter A., Zhai Chuangyan, Rangger Christine, Nuclear Medicine and Biology . 2015 ,第2期

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4. Preparation and Properties of Palladium Complexes of 1,3-Diphosphapropene Derivatives [C] . Katsunori Nishide, Hongze Liang, Shigekazu Ito, Symposium on Organometallic Chemistry . 2004

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5. Part I. Synthesis, properties, and applications of oligosubstituted bullvalenes. Part II. Preparation of C-terminal α-ketoacids and N-terminal hydroxylamines for decarboxylative peptide ligations [D] . Lippert, Alexander Ryan 2008

机译：第一部分。寡取代的丁二烯的合成，性质和应用。第二部分用于脱羧肽连接的C端α-酮酸和N端羟胺的制备
6. 68GaFSC-(RGD)3 a trimeric RGD peptide for imaging αvβ3 integrin expression based on a novel siderophore derived chelating scaffold—synthesis and evaluation [O] . Peter A. Knetsch, Chuangyan Zhai, Christine Rangger, -1

机译：68Ga FSC-（RGD）3三聚体RGD肽用于基于新型铁载体衍生的螯合支架对αvβ3整联蛋白表达进行成像-合成和评价
7. A comparative study of peptide-based imaging agents 68GaGa-PSMA-11, 68GaGa-AMBA, 68GaGa-NODAGA-RGD and 68GaGa-DOTA-NT-20.3 in preclinical prostate tumour models [O] . Jules Zhang-Yin, Claire Provost, Géraldine Cancel-Tassin, 2020

机译：肽基成像剂68Ga Ga-psma-11，68ga Ga-Amba，68ga Ga-nodaga-RGD和68ga Ga-dota-nt-20.3在临床前前列腺肿瘤模型中的比较研究
8. The Preparation and Properties of Organic Derivatives of Peroxides of Elements Other Than Carbon [R] . Dannley, R. L. 1969

机译：碳以外元素过氧化物有机衍生物的制备及性质

Preparation and Properties of ~(68)Ga Complexes with RGD Peptide Derivatives

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