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Diabetic macular edema associated with glitazone use.

机译:与格列酮使用相关的糖尿病性黄斑水肿。

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PURPOSE: To describe diabetic macular edema (DME) in patients who developed fluid retention as a consequence of glitazone use. METHODS: A chart review identified 30 patients who used pioglitazone or rosiglitazone and had both lower extremity edema and macular edema. Clinical reports, photographs, and fluorescein angiograms were reviewed. Patients followed for >3 months were analyzed separately. RESULTS: Seventeen patients took oral pioglitazone, 11 took rosiglitazone, and 2 took both drugs at different times. Eleven patients were observed for >3 months after cessation of glitazones. Mean weight gain during drug administration in this group was 30 lb, and mean weight loss after drug discontinuation was 19 lb. Rapid reduction in macular edema off drug occurred in only 4 of 11 patients, but 8 of 11 had reduced edema over 2 years. Mean visual acuity in this group at the initial visit was 20/60, and at the final visit, it was 20/85. Four eyes of three patients had resolution of diffuse macular edema with improved vision after cessation of glitazones without laser treatment. CONCLUSIONS: Fluid retention occurs in 5% to 15% of patients taking glitazones. In some of these patients, glitazone use appears to be a cause of macular edema, and drug cessation appears to result in rapid resolution of both peripheral and macular edema. Fluid retention associated with glitazone use should be considered when assessing treatment options for patients with DME, especially those with concomitant peripheral edema.
机译:目的:描述由于使用格列酮而导致液体retention留的患者的糖尿病性黄斑水肿(DME)。方法:通过图表审查确定了使用吡格列酮或罗格列酮的30例患者,同时患有下肢水肿和黄斑水肿。回顾了临床报告,照片和荧光素血管造影。随访超过3个月的患者被单独分析。结果:17例患者口服吡格列酮,11例服用罗格列酮,2例同时服用两种药物。格列酮类药物停药后,有11例患者进行了3个月以上的观察。该组在给药期间的平均体重增加为30磅,停药后的平均体重减轻为19磅。11例患者中只有4例快速减少黄斑水肿,但是11例中有8例在2年内出现了水肿减轻。该组在初次就诊时的平均视力为20/60,在最后一次就诊时为20/85。三名患者中的四只眼在未使用激光治疗的情况下戒断了格列酮后,弥散性黄斑水肿消失,视力得到改善。结论:服用格列酮的患者中有5%至15%发生体液Fluid留。在其中一些患者中,格列酮的使用似乎是引起黄斑水肿的原因,戒烟似乎可以迅速消除周围和黄斑水肿。在评估DME患者(尤其是伴有周围性水肿的患者)的治疗选择时,应考虑与格列酮使用有关的体液retention留。

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