Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives

摘要

A series of new 3-arylsulfonylimidazolidine-2,4-diones (2a-2p) were synthesized by reacting imidazolidine-2,4-diones (1a-1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones (1a-1e) were in turn synthesized from the corresponding ketones through Bucherer-Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR, H-1 and C-13 NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds (2a-2p) was evaluated using alloxanized diabetic rat model. Compound 2a showed an excellent activity with a reduction in the blood glucose level of -286 +/- A 7 mg/dL after 5 h of drug administration as compared to -270 +/- A 8 mg/dL for glipizide. The hypoglycemic activity of compound 2b (-268 +/- A 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound 2e.