Montmorillonite-KSF-catalyzed synthesis of 4-heteroarylidene-N-arylhomophthalimides by Knoevenagel condensation

摘要

A simple, efficient and rapid method for clay-catalyzed Knoevenagel condensation of heterocyclic aldehydes with active methylene compound under reflux condition is reported. This protocol offers high yield, shorter time and simple work procedure. The protocol does not require column chromatography for purification, and the process is environmentally benign.