Secondary amines immobilized inside magnetic mesoporous materials as a recyclable basic and oxidative heterogeneous nanocatalyst for the synthesis of trisubstituted pyrimidine derivatives

摘要

A novel magnetic MCM-41 nanocomposite-based catalyst is reported for the first time in the multicomponent synthesis of trisubstituted pyrimidines in which piperazine is immobilized inside the mesochannels of magnetic MCM-41 as an organic base (alpha-Fe2O3-MCM-41-piperazine). This nanocatalyst was thoroughly characterized by various techniques such as FT-IR, XRD, SEM, TEM, EDX and N-2-adsorption isotherms. Very uniform dispersion and ordered mesopores of alpha-Fe2O3-MCM-41 causes piperazine molecules to be distributed very finely on the internal surface of the pores, resulting in a very useful and robust magnetically recyclable amine-based heterogeneous nanocatalyst. This catalytic system showed remarkable activity in the solvent-free synthesis of 2,4,6-trisubstituted pyrimidine derivatives.