Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

Bakr Ali; Kocher Sabrina; Volquardsen Jennifer; Reimer Rudolph; Borgmann Kerstin; Dikomey Ekkehard; Rothkamm Kai; Mansour Wael Y.

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Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

机译：DNA损伤反应蛋白53BP1和BRCA1之间的功能性串扰调节双链断裂修复选择

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Purpose: The aim of this study was to elucidate the impact of DNA damage response (DDR) proteins 53BP1 and BRCA1 on the double-strand break (DSB)-repair choice. This is important not only in order to understand the underlying mechanisms of DSB-repair pathway regulation but also to determine the therapeutic implications for BRCA1-associated tumors.

机译：目的：本研究的目的是阐明DNA损伤应答（DDR）蛋白53BP1和BRCA1对双链断裂（DSB）修复选择的影响。这不仅对于了解DSB修复途径调控的潜在机制，而且对于确定BRCA1相关肿瘤的治疗意义都很重要。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2016年第2期|共6页
作者
Bakr Ali; Kocher Sabrina; Volquardsen Jennifer; Reimer Rudolph; Borgmann Kerstin; Dikomey Ekkehard; Rothkamm Kai; Mansour Wael Y.;
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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
53BP1; BRCA1; DSB-repair choice;

机译：53BP1;BRCA1;DSB修复选择;

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专利

1. Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice [J] . Bakr Ali, Kocher Sabrina, Volquardsen Jennifer, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2016,第2期

机译：DNA损伤反应蛋白53BP1和BRCA1之间的功能性串扰调节双链断裂修复选择
2. PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection [J] . Vincent Pennaneach, Janet Hall, Bernard Lopez, Nucleic acids research . 2017,第21期

机译：PARP2通过限制DNA损伤部位的53BP1积累并促进末端切除来控制双链断裂修复途径的选择
3. 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks [J] . James M. Daley, Patrick Sung Molecular and Cellular Biology . 2014,第8期

机译：53BP1，BRCA1，以及在DNA双链断裂处进行重组和末端连接之间的选择
4. In vitro binding kinetics of DNA double strand break repair proteins Ku70/80 and DNA-PKcs quantified by fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy [C] . Salim Abdisalaam, George Alexandrakis Single Molecule Spectroscopy and Superresolution Imaging V. . 2012

机译：DNA双链断裂修复蛋白Ku70 / 80和DNA-PKcs的体外结合动力学通过荧光相关光谱和荧光互相关光谱定量
5. DNA Damage Response Pathways in DNA Double Strand Break Repair and Hepatic Metabolism [D] . Moore, Elizabeth S. 2019

机译：DNA损伤反应途径在DNA双链断裂修复和肝代谢
6. PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection [O] . Alexis Fouquin, Josée Guirouilh-Barbat, Bernard Lopez, 2017

机译：PARP2通过限制DNA损伤部位的53BP1积累并促进末端切除来控制双链断裂修复途径的选择
7. 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks [O] . James M. Daley, Patrick Sung 2014

机译：53bp1，brca1，重组和结束在DNA双链断裂之间的选择

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

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