gamma H2AX assay in ex vivo irradiated tumour specimens: A novel Method to determine tumour radiation sensitivity in patient-derived material

Menegakis Apostolos; von Neubeck Claere; Yaromina Ala; Thames Howard; Hering Sandra; Hennenlotter Joerg; Scharpf Marcus; Noell Susan; Krause Mechthild; Zips Daniel; Baumann Michael

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gamma H2AX assay in ex vivo irradiated tumour specimens: A novel Method to determine tumour radiation sensitivity in patient-derived material

机译：体外照射的肿瘤标本中的γH2AX测定：一种确定患者来源材料中肿瘤放射敏感性的新方法

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Purpose: To establish a clinically applicable protocol for quantification of residual gamma H2AX foci in ex vivo irradiated tumour samples and to apply this method in a proof-of-concept feasibility study to patient-derived tumour specimens.

机译：目的：建立定量用于离体辐射肿瘤样品中残留γH2AX病灶的临床适用方案，并将该方法应用于源自患者的肿瘤标本的概念验证可行性研究中。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2015年第3期|共7页
作者
Menegakis Apostolos; von Neubeck Claere; Yaromina Ala; Thames Howard; Hering Sandra; Hennenlotter Joerg; Scharpf Marcus; Noell Susan; Krause Mechthild; Zips Daniel; Baumann Michael;
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正文语种 eng
中图分类肿瘤学;
关键词
gamma H2AX foci; Radiotherapy; DNA repair; Tumour biopsy; Biomarker;

机译：γH2AX灶;放射治疗;DNA修复;肿瘤活检;生物标志物;

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1. gamma H2AX assay in ex vivo irradiated tumour specimens: A novel Method to determine tumour radiation sensitivity in patient-derived material [J] . Menegakis Apostolos, von Neubeck Claere, Yaromina Ala, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第3期

机译：体外照射的肿瘤标本中的γH2AX测定：一种确定患者来源材料中肿瘤放射敏感性的新方法
2. Ex vivo gamma H2AX assay in prostate cancer patient tumour samples reveals substantial differences in intrinsic radiation sensitivity [J] . De Colle C., Menegakis A., Mueller A. -C, Strahlentherapie und Onkologie . 2016,第Suppla1期

机译：前列腺癌患者肿瘤样本中的前体内γH2AX测定揭示了内在辐射敏感性的显着差异
3. Residual gamma H2AX foci after ex vivo irradiation of patient samples with known tumour-type specific differences in radio-responsiveness [J] . Menegakis Apostolos, De Colle Chiara, Yaromina Ala, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第3期

机译：离体辐射患者样品的放射性反应后已知肿瘤类型特异性差异后的残留γH2AX灶
4. Survival of Rats with N29 Brain Tumours after Irradiation with 5 or 15 Gy and Immunization with IFN-gamma Secreting Tumour Cells [C] . Bertil R. R. Persson, Catrin Baureus Koch, Gustav Grafstrom, International Conference on Biomedical Engineering and Informatics . 2008

机译：用IFN-Gamma分泌肿瘤细胞的5或15 Gy和IFN-Gamma的免疫接种，对N29脑肿瘤的大鼠存活
5. Characterization of drug and radiation sensitivity mechanisms in human hepatocellular carcinoma Hep G2 cells after fractionated gamma-irradiation. [D] . Tang, Wan-yee. 2004

机译：分级γ射线照射后人肝细胞癌Hep G2细胞的药物敏感性和放射敏感性机制的表征。
6. Section 6: Sensitization and Hypoxic Cytotoxicity: Effects of Hyperthermia and High Let: In vivo Assay of the Radiation Sensitivity of Hypoxic Tumour Cells; Influence of γ-rays Cyclotron Neutrons Misonidazole Hyperthermia and Mixed Modalities [O] . W. Porschen, J. Gartzen, K. Gewehr, 1978

机译：第6节：致敏性和低氧细胞毒性：高热和高致死量的影响：低氧肿瘤细胞辐射敏感性的体内测定； γ射线回旋加速器中子咪唑热疗和混合模态的影响
7. Residual γH2AX foci after ex vivo irradiation of patient samples with known tumour-type specific differences in radio-responsiveness [O] . Apostolos Menegakis, Chiara De Colle, Ala Yaromina, 2015

机译：残留γH2AX焦点在患者样品中的患者样品中具有已知的肿瘤型特异性差异的无线电反应性

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gamma H2AX assay in ex vivo irradiated tumour specimens: A novel Method to determine tumour radiation sensitivity in patient-derived material

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