Zerumbone's Effect on Major Histocompatibility Complex Type II Cells in Synovial Membrane of OsteoArthritic. Joint*

摘要

Effect of zerumbone on the infiltration major histocompatibility complex class II cells were evaluated in rats with collagen-induced osteoarthritis. The changes in the number of these cells were compared between the corn oil and the zerumbone treatedgroup. The results showed that the number of MHC class Il-immunoreactivity was significantly reduced in zerumbone treated group compared to the com oil group and only type A cells were positive for MHC II staining. Therefore, present results suggest thatzerumbone has the property of inhibiting the antigen presenting cells (type A) which is present during inflammation, thus reducing the inflammatory process in osteoarthritis.