Evaluation of antibacterial and toxicological effects of a novel sodium silicate complex

摘要

The potential for a sodium silicate complex (SSC) to reduce Post-harvest contamination of foods and water was evaluated in antibacterial activity assays against four Gram positive, Gram negative and clinically isolated multidrug resistant strains of bacteria. SSC inhibited the growth of all bacterial strains and the Minimal inhibitory Concentration (MIC90) was in the range of 21.3-26.6 μg mL -1 for Gram negative bacteria, 10.6-53.2 μg mL -1 for Gram positive bacteria and 42.5-212.7 μg mL -1 the antibiotic resistant strains. Additionally, the Lethal Dose (LD 50) for acute oral toxicity of SSC determined in Female Albino Sprague-Dawley rats by oral gavaging was found to be 5000 mg kg -1, Results suggest potential pharmaceutical, food safety and water quality application of SSC and merits further investigation.