Application of 32 Factorial Design in the Formulation of Fast Release Olmesartan Medoxomil Liquisolid Tablets

摘要

Fast dissolving tablets are gaining more importance in the market day by day and are available in the market for treating many disease conditions. Olmesartan medoxomil (OLM) is the novel antihypertensive drug having specific angiotensin II type 1 antagonist activity and used in the management of acute and chronic hypertension. Rapid onset of action is desirable to provide fast relief in the treatment of heart failure. Hence, it is necessary to enhance dissolution rate of OLM to obtain faster on set of action, minimize the variability in absorption, and improve its overall oral bioavailability. Liquisolid technique was used to enhance the aqueous solubility and dissolution rate to obtain faster on set of action, minimize the variability in absorption, and improve its oral bioavailability. The aim of the present study was to formulate OLM liquisolid tablets. A 32factorial design was applied to investigate the combine effect of Neusilin US2 (carrier material) and Aerosil 200 (coating material). The angles of repose and % drug release were selected as dependent variables. Liquisolid systems of OLM were evaluated for pre and post compression parameters. In vitro drug release studies showed highest drug release at initial bursting of tablet at 2 min. The results of a 32 full factorial design revealed that the amount of Neusilin US2 and Aerosil 200 significantly affect the dependent variables, angle of repose and % drug release. Higuchi model was found to be the best fit model for the optimized batch. Thus Neuslin US2 should be in high concentration and Aerosil 200 should be in low concentration i.e high R value which gives the enhanced solubility and hence fast dissolution i.e. onset of action is obtained.