miR-181a mediates TGF-beta-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer

Brockhausen Jennifer; Tay Szun S.; Grzelak Candice A.; Bertolino Patrick; Bowen David G.; dAvigdor William M.; Teoh Narcy; Pok Sharon; Shackel Nick; Gamble Jennifer R.; Vadas Mathew; McCaughan Geoff W.

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miR-181a mediates TGF-beta-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer

机译：miR-181a介导TGF-β诱导的肝细胞EMT，在肝硬化和肝细胞癌中失调

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Background & AimsEpithelial-mesenchymal transition (EMT) has been implicated in the processes of embryogenesis, tissue fibrosis and carcinogenesis. Transforming growth factor- (TGF-) has been identified as a key driver of EMT and plays a key role in the pathogenesis of cirrhosis and hepatocellular carcinoma (HCC). The aim was to identify microRNA (miR) expression in TGF--induced hepatocyte EMT.

机译：背景与目的上皮间质转化（EMT）与胚胎发生，组织纤维化和致癌过程有关。转化生长因子-（TGF-）已被确定为EMT的关键驱动力，并且在肝硬化和肝细胞癌（HCC）的发病机理中起关键作用。目的是鉴定在TGF诱导的肝细胞EMT中的microRNA（miR）表达。

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《Liver international :》 |2015年第1期|共14页
作者
Brockhausen Jennifer; Tay Szun S.; Grzelak Candice A.; Bertolino Patrick; Bowen David G.; dAvigdor William M.; Teoh Narcy; Pok Sharon; Shackel Nick; Gamble Jennifer R.; Vadas Mathew; McCaughan Geoff W.;
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正文语种 eng
中图分类内科学;
关键词
cirrhosis; EMT; hepatocellular carcinoma; hepatocyte; microRNA; TGF-beta;

机译：肝硬化;EMT;肝细胞癌;肝细胞;microRNA;TGF-β;

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专利

1. miR-181a mediates TGF-beta-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer [J] . Brockhausen Jennifer, Tay Szun S., Grzelak Candice A., Liver international : . 2015,第1期

机译：miR-181a介导TGF-β诱导的肝细胞EMT，在肝硬化和肝细胞癌中失调
2. LEF1 targeting EMT in prostate cancer invasion is mediated by miR-181a [J] . Jiaqian Liang, Xin Li, Yirong Li, American Journal of Cancer Research . 2015,第3期

机译：miR-181a介导LEF1在前列腺癌侵袭中靶向EMT
3. Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting [J] . Seydi Enayatollah, Salimi Ahmad, Rasekh Hamid Reza, Nutrition and Cancer: An International Journal . 2018,第1a4期

机译：从肝细胞癌大鼠模型中获得的癌性肝细胞癌肝细胞的选择性细胞毒性：ROS介导的线粒体靶向的参与
4. Effective and cancer-specific siRNA delivery to human hepatocellular carcinoma cells mediated by poly(beta-amino ester) nanoparticles [C] . Camila Zamboni, Kristen K Kozielski, Nicholas Radant, World biomaterials congress . 2016

机译：聚（β-氨基酯）纳米粒子介导的有效且癌症特异性的siRNA递送至人肝癌细胞
5. Development and Characterization of a Large Animal Model of Hepatocellular Carcinoma and Liver Cirrhosis [D] . Gaba, Ron. 2019

机译：肝细胞癌和肝硬化大型动物模型的发展与鉴定
6. LEF1 targeting EMT in prostate cancer invasion is mediated by miR-181a [O] . Jiaqian Liang, Xin Li, Yirong Li, 2015

机译：miR-181a介导LEF1在前列腺癌侵袭中靶向EMT
7. Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer [O] . Santoshi Muppala, Roy Xiao, Jasmine Gajeton, 2020

机译：血压素-4介导乳腺癌中的高血糖和TGF-Beta诱导的炎症

miR-181a mediates TGF-beta-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer

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