Effect of a single intrauterine administration of recombinant bovine interferon-tau on day 7 of the estrous cycle on the luteal phase length and blood profile in dairy cows.

摘要

This study tested the effect of recombinant bovine interferon-tau (rboIFN-tau) on the length of estrous cycle, luteal lifespan and side effects of rboIFN-tau in the cow. A normal estrous cycle in six non-lactating cycling Holstein cows was observed (non-treated cycle), and either 2.0 mg of liposomalized rboIFN-tau (treated cycle) or bovine serum albumin (BSA; placebo cycle) was infused in the uterus on day 7 of the estrous cycle (day 0=day of ovulation). Rectal temperature, heart rate and respiratory rate were recorded and blood samples were collected before and after the treatments. The length of the estrous cycle and corpus luteum lifespan in rboIFN-tau treated cycles were not significantly different from those of the non-treated and placebo cycles. In contrast, the rboIFN-tau treatment caused a transient increase in rectal temperature and a decrease in the number of peripheral lymphocytes and neutrophils after the treatment. Copyright Copyright 2011 Elsevier Ltd. All rights reserved.