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Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease

机译:猪圆环病毒2型相关呼吸道疾病猪肺中促炎细胞因子的表达

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摘要

Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-gamma, IL-1 alpha, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1 alpha and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease
机译:2型猪圆环病毒(PCV2)对全世界的养猪业造成严重的健康问题。在这项研究中,我们调查了PCV2相关呼吸道疾病猪的肺中的细胞因子表达谱(IFN-γ,IL-1α,IL-8和IL-10)。在与PCV2相关的呼吸系统疾病的猪中,IL-1α和IL-8的mRNA表达显着上调,而未检测到IL-10的表达。这些结果表明,肺炎性细胞因子表达的增加可能在与PCV2相关的呼吸道疾病的猪的免疫病理反应中起重要作用

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