Intensity-Based Deformable Image Registration with Anatomical Constraints for Adaptive Radiation Therapy

摘要

We propose a deformable image registration algorithm that incorporates shape constraints into an intensity-based diffusion algorithm. The shape of a target is represented by a set of landmark pairs delineated by automatic algorithm or by user selected points in an image pair to be registered. The landmark pairs are used as control points to create a spline function in the form of linear combinations of radial bases as shape constraints to regularize the deformation vector field created by the intensity-based algorithm. The algorithm starts with an intensity-based image registration to establish voxel-by-voxel correspondences.