Fast Dissolving/Disintegrating Dosage Forms: Growth from Immediate Release to Sustained Release and Traditional Medicines

摘要

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are formulated and developed for immediate drug delivery, quicker onset of action, and/or as age appropriate dosage forms meant for special populations like paediatrics, psychotic, dysphagic, and frequent traveller patients. FDDFs family include tablets (FDTs), oral films (FDOF), mini tablets, capsules, pellets, granules, etc. FDDFs dissolve/ disintegrate quickly in saliva resulting in solution/suspension for oral ingestion and thereby eliminate the need for water for swallowing the dosage form.FDTs market, in regions of US, Europe, and Japan, grew more than $8.4 billion in 2011 and is expected to reach to $12 billion globally by 2018 [1]. FDOF market is expected to attain $1 billion mark in 2015 [1]. FDDFs have successfully entered in Pharmacopoeia as Orally Disintegrating Tablets (US and Japan) or Orodis-persible Tablets (ODT or OD Tablet) [Europe and Japan] and orodispersible films (ODF) [Europe]. FDDFs have recently shifted their focus beyond immediate release FDDFs to controlled/sustained release FDDFs for phytopharmaceuticals and traditional medicines.