Nonalcoholic Fatty Liver Disease After Liver Transplantation for Cryptogenic Cirrhosis or Nonalcoholic Fatty Liver Disease

摘要

Nonalcoholic steatohepatitis (NASH) may account for many cases of cryptogenic cirrhosis. If so, then steatosis might recurafter liver transplantation. Two thousand fifty-two patients underwent primary liver transplantation for chronic liver diseasebetween 1986 and 2004. Serial liver biopsy samples were assessed for steatosis and fibrosis. Two hundred fifty-sevenpatients (12%) had a pretransplant diagnosis of cryptogenic cirrhosis (239) or NASH (18). Fatty liver developed in 31% andwas more common when the pretransplant diagnosis was NASH (45% at 5 years versus 23% for cryptogenic cirrhosis, P =0.007). NASH developed in only 4% and occurred exclusively when steatosis had already occurred. Steatosis after livertransplantation was associated with the baseline body weight and body mass index by univariate analyses, but no pretrans-plant or posttransplant characteristic independently predicted steatosis after liver transplantation because obesity was socommon in all groups. Five percent and 10% developed bridging fibrosis or cirrhosis after 5 and 10 years, respectively, andthis was more common after NASH (31%) than in those who developed steatosis alone (6%) or had no fat (3%, P =0.002). One-, 5-, and 10-year survival was the same in patients who underwent transplantation for cryptogenic cirrhosis orNASH (86%, 71%, and 56%) and in patients who underwent transplantation for other indications (86%, 71%, and 53%; notsignificant), but death was more often due to cardiovascular disease and less likely from recurrent liver disease. In conclu-sion, fatty liver is common after liver transplantation for cryptogenic cirrhosis or NASH but is twice as common in the lattergroup; this suggests that some cryptogenic cirrhosis, but perhaps not all, is caused by NASH. Posttransplant NASH is un-usual, and steatosis appears to be a prerequisite. Advanced fibrosis is uncommon, and survival is the same as that ofpatients who undergo transplantation for other causes.