Gut microbe-host metabolic interactions in health and disease: Exploring host and gut microbiota connections could uncover the mechanisms of various diseases along with targets for drugs with which to treat them

摘要

Complex host-microbial interactions are essential for health and, when disrupted, can give rise to a wide variety of diseases. Microbial functions might help to account for host metabolic disorders such as obesity and diabetes. Bariatric surgery to control obesity may work, in part, by perturbing the gut microbiota, changing metabolic dynamics, and leading to long-term weight loss. Accruing evidence suggests that gut microbes can affect brain development and behavior.