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首页> 外文期刊>Life sciences >Angiotensin II induces prostaglandin E(2) release in human gingival fibroblasts.
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Angiotensin II induces prostaglandin E(2) release in human gingival fibroblasts.

机译:血管紧张素II诱导人牙龈成纤维细胞中前列腺素E(2)的释放。

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We investigated the effect of angiotensin II on prostaglandin E(2) release in human gingival fibroblasts. Stimulation of human gingival fibroblasts with angiotensin II elicited prostaglandin E(2) release in a concentration- and time-dependent manner. Angiotensin III also induced prostaglandin E(2) release, but the effect was weaker than that of angiotensin II. Angiotensin II- and angiotensin III-induced prostaglandin E(2) release was inhibited by AT(1) receptor antagonist FR-130,739, but not AT(2) receptor antagonist PD-123,319. Angiotensin II evoked an increase in intracellular Ca(2+) in fura-2-loaded human gingival fibroblasts. These results suggest that angiotensin II functions as a physiological mediator via Ca(2+)-mobilizing AT(1) receptor activation in human gingival fibroblasts.
机译:我们调查了血管紧张素II对人牙龈成纤维细胞中前列腺素E(2)释放的影响。人牙龈成纤维细胞与血管紧张素II的刺激引起前列腺素E(2)释放以浓度和时间依赖的方式。血管紧张素III也诱导前列腺素E(2)释放,但作用比血管紧张素II弱。血管紧张素II和血管紧张素III诱导的前列腺素E(2)释放被AT(1)受体拮抗剂FR-130,739抑制,但不受AT(2)受体拮抗剂PD-123,319抑制。血管紧张素II引起呋喃2加载人类牙龈成纤维细胞中细胞内Ca(2+)的增加。这些结果表明,血管紧张素II通过人类牙龈成纤维细胞中的Ca(2+)动员AT(1)受体激活而充当生理介质。

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