Palladium-Catalyzed Decarboxylative Csp(2)-Csp(2) Cross-Coupling Reactions: An Efficient Route for Synthesis of Azaisoflavone Derivatives

摘要

An efficient and step-economical ligand-free palladium-catalyzed decarboxylative functionalization of quinolinone-3-carboxylic acids has been well developed. Note that the reaction could proceed smoothly under an argon atmosphere at relatively low temperature by using Pd(OAc)(2) as the catalyst and Ag2CO3 as the oxidant. In this protocol, various functionalities were compatible under the reaction condition, and a series of biologically important azaisoflavone derivatives were obtained in moderate to high yields.