Independent coexistence of clones with 13q14 deletion at reciprocal translocation breakpoint and 13q14 interstitial deletion in chronic lymphocytic leukemia

摘要

13ql4 deletion is the most frequent chromosomal aberration in chronic lymphocytic leukemia (CLL), found by interphase fluorescence in situ hybridization (FISH) in more than 50% of cases of CLL [1]. As a sole aberration it is associated with a favorable prognosis; however, it (13ql4 deletion) does not improve the impaired prognosis of complex karyotype [1,2]. A minimal deleted region (MDR) of approximately 900 kbp in size was established by genomic profiling [3], containing several genes including DLEU7 and miR15a and miR16-1, recognized as tumor suppressor genes [4-6]. Deletion larger than the MDR was repeatedly associated with an increased risk of disease progression [3,7].