Analysis of interleukin-10 promoter single nucleotide polymorphisms and risk of non-Hodgkin lymphoma in a Malaysian population

摘要

We evaluated the association of two IL10 single nucleotide polymorphisms (SNPs) (rs1800896 and rs1800871) with non-Hodgkin lymphoma (NHL) risk in the three major races of the Malaysian population (Malay, Chinese and Indian; 317 cases and 330 controls). Our initial screening demonstrated that rs1800871 but not rs1800896 was significantly associated with increased NHL risk in Malays (p(Malay-Rec) = 0.007) and Chinese only (p(Chinese-Rec) = 0.039). Subsequent combined analysis of the Malay and Chinese revealed significant association of rs1800871 with all (ALL) NHL subtypes (p(Meta-ALL-NHL-Rec) = 0.001), ALL B-cell subtypes (p(Meta-ALL-B-cell-Rec) = 0.003), diffuse large B-cell lymphoma (DLBCL) subtype (p(Meta-DLBCL-Rec) = 0.002) and ALL T-cell subtypes (p(Meta-ALL-T-cell-Rec) = 0.031). SNP rs1800896 showed increased risk only in follicular lymphoma (FL) (p(Meta-FL-Dom) = 0.0004). We also detected a male-specific association of rs1800871 with increased NHL risk (p(Meta-Male-ALL-NHL-Rec) = 0.006) in the combined analysis. To our knowledge, this is the first report on the association of IL10 promoter SNPs with NHL susceptibility in the three major races of Malaysia.