Association Between the Interleukin-10-1082G/A,-592C/A,-819C/T Gene Polymorphism and HIV-1 Susceptibility: A Meta-Analysis

摘要

The Interleukin-10 (IL-10) gene polymorphism influences the pathogenesis and evolution of HIV-1 disease. Many studies in this regard have evaluated the association between this polymorphism and HIV-1 susceptibility, yet, the exact relationship between them remains ambiguous and contradictory. A systematic literature search was conducted and the found case-control studies assessing the association between IL-10-1082G/A, -592C/A, -819C/T gene polymorphism and HIV-1 susceptibility were analyzed. The pooled odds ratios (ORs) and 95 confidence interval (CI) were calculated by a fixed effect model. In general, no significant relationship was found between IL-10-1082G/A gene polymorphism and susceptibility to HIV-1 infection (A vs. G genotype model: OR=0.97, 95 CI=0.81-1.23, p=.775; GG vs. AA+AG model: OR=0.98, 95 CI=0.76-1.27, p=.867; GG+AG vs. AA model: OR=0.97, 95 CI=0.70-1.35, p=.852; GG vs. AA model: OR=0.88, 95 CI=0.67-1.15, p=.348; AG vs. AA model: OR=0.96, 95 CI=0.67-1.37, p=.811; GG+ AA vs. AG model: OR=1.03, 95 CI=0.74-1.43, p=.886). IL-10-529C/A gene polymorphism might lead to a decreased risk of HIV-1 infection (A vs. G genotype model: OR=0.88, 95 CI=0.73-1.06, p=.166; GG vs. AA+ AG model: OR=0.94, 95 CI=0.80-1.11, p=.447; GG+ AG vs. AA model: OR=0.75, 95 CI=0.61-0.92, p=.005; GG vs. AA model: OR=0.73, 95 CI=0.57-0.93, p=.012; AG vs. AA model: OR=0.74, 95 CI=0.60-0.92, p=.0.007; GG+ AA vs. AG model: OR=1.11, 95 CI=0.72-1.71, p=.641). IL-10-819C/T gene polymorphism might lead to an increased risk of HIV-1 infection (A vs. G genotype model: OR=1.25, 95 CI=1.04-1.50, p=.019; GG vs. AA+ AG model: OR=1.29, 95 CI=0.81-2.01, p=.278; GG+ AG vs. AA model: OR=1.42, 95 CI=1.05-1.93, p=.023; GG vs. AA model: OR=1.63, 95 CI=1.11-2.38, p=.012; AG vs. AA model: OR=1.32, 95 CI=0.95-1.84, p=.094; GG+ AA vs. AG model: OR=0.92, 95 CI=0.72-1.19, p=.537). In general, the meta-analysis found no marked association between the IL-10-1082G/A gene polymorphism and HIV-1 susceptibility, IL-10-529C/A gene polymorphism might lead to a decreased risk of HIV-1 infection, and IL-10-819C/T gene polymorphism might lead to an increased risk of HIV-1 infection.