Numerous methods have been developed to improve imaging within turbid or scattering media such as human tissue. Although laser speckle imaging (LSI) has been successful for before-and-after blood-flow analysis in patients undergoing laser-based port wine stain (PWS) treatment, hardware and processing issues have limited LSI to pre-and post-treatment analysis only. But recent developments from a team of researchers at the Beckman Laser Institute and Medical Clinic at the University of California-Irvine now provide physicians with real-time feedback during PWS treatment, improving the efficacy of these laser-based procedures for the 0.3-0.5% of the population born with this birthmark annually.
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