Increasing Proteome Coverage with ETD and CID in One Run Using Intelligent Data-Dependent Decision Tree Logic

摘要

Since the addition of electron transfer dissociation (ETD) to the Thermo Scientific LTQ Orbitrap hybrid mass spectrometers, ETD has become a standard tool for proteomics research together with the traditional collision-induced dissociation (CID) (1). Whereas CID produces y- nd b-fragment ions, ETD predominantly produces c- and z-type fragment ions.