Effect of defatted rice bran supplementation on metabolic parameters and inflammatory status in overweight/obese adults with hypercholesterolemia: a randomized, placebo-controlled intervention

摘要

Background: Defatted rice bran (DRB) is a byproduct of rice bran oil production rich in fiber, protein, and antioxidant compounds that may confer beneficial effects on metabolic profiles in humans. The current study aimed to investigate the effects of DRB supplementation on anthropometric and blood biochemical indices, dietary intake, and inflammatory status in overweight/obese subjects with hypercholesterolemia. Methods: In a 12-week-randomized placebo-controlled trial, 61 overweight/obese participants with a total cholesterol level >200 mg/dL were randomly assigned either to 30 g/d DRB (n = 30) or to 10 g/d maltodextrin (n = 31). Results: DRB intervention significantly reduced systolic and diastolic blood pressure by 4.27 and 4.50, respectively (126.20 +/- 13.63 to 120.60 +/- 13.72 mmHg, p= 0.0003 and 80.87 +/- 7.38 to 77.17 +/- 9.83 mmHg, p= 0.0035). HbA1c also decreased significantly by 3.59 (5.89+/- 0.76 to 5.66 +/- 0.62, p= 0.0001) after DRB supplementation. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels also decreased insignificantly by 3.12, 1.32, and 1.53, respectively, after DRB supplementation. Insignificant differences in fasting blood glucose, insulin, homeostatic model assessment of insulin resistance, quantitative insulin sensitivity check index, hs-CRP and homocysteine levels were also observed after DRB intervention. Reduction in caloric and fat intake were reported in DRB groups. Conclusions: DRB supplementation improved blood pressure and HbA1c levels. It also lowered blood cholesterol, albeit insignificantly. Caloric and fat intake were also significantly lower after DRB supplementation. Further study is needed to evaluate the mechanisms by which DRB improves these metabolic indices.