摘要:Objective:To study the chemical composition,anticancer,anti-neuroinflammatory,and antioxidant activities of the essential oil of Patrinia scabiosaefolia(EO-PS).Methods:Patrinia scabiosaefolia was analyzed by gas chromatography-mass spectrometry.Eight human carcinoma cell lines,including SGC-7901,AGS,Hep G2,HT-29,HCT-8,5-FU/HCT-8,He La,and MDA-MB-231,were assessed by methylthiazolyldiphenyltetrazolium bromide(MTT) assay.Anti-neuroinflammatory activity was assessed by production of interleukin(IL)-1β and IL-6 induced by lipopolysaccharide in BV-2 cells(microglia from mice).The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay.Results:Forty-four components,representing 83.919% of the total oil,were identified in the EO-PS.The major constituents were caryophyllene oxide(12.802%),caryophyllene(6.909%),α-caryophyllene(2.927%),β-damascenone(3.435%),calarene(5.621%),and phenol(3.044%).The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/m L dilution range.The EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical,with an half of maximal inhibitory concentration 1.455 mg/m L.Conclusion:The EO-PS possesses a wide range of antitumor,anti-neuroinflammatory and antioxidant activities,suggesting that it may be a good candidate for further investigations of new bioactive substances.