Potential early markers of Parkinson's disease in idiopathic rapid-eye-movement sleep behaviour disorder.

摘要

Despite substantial advances in the understanding of neurodegenerative disorders such as Parkinson's disease (PD), no treatment has been developed to slow or stop the underlying neurodegeneration. Perhaps one important reason for this is that by the time a patient is diagnosed with the disorder, the neurodegenerative process has been established for many years. The identification of the presymptomatic stage of a disease like PD may provide a window of opportunity to intervene in the disease process before it is too late.Rapid-eye-movement sleep behaviour disorder (RBD) is a fascinating disorder characterised by a failure of the normal brainstem-mediated: processes that paralyse us while we dream: patients may cry out, punch, kick, or leap out of bed in response to dream content. Clonazepam is a highly effective treatment that provides long-term suppression of symptoms in most patients.