Chromosome 9p21 in amyotrophic lateral sclerosis: the plot thickens

摘要

In this issue of The Lancet Neurology, two groups report the results of genome-wide association studies (GWAS) in patients from Finland and the UK in which amyotrophic lateral sclerosis (ALS) was found to be significantly associated with a region of chromosome 9p21. Although a new susceptibility gene or locus for ALS was not identified, these findings nonetheless emphasise the importance of chromosome 9p, and in particularthe 9pl33-21.3 locus, in ALS.