首页> 外文期刊>Nutrition, metabolism, and cardiovascular diseases: NMCD >Effects of garlic extract on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aorta.
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Effects of garlic extract on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aorta.

机译:大蒜提取物对家兔主动脉中氧化剂/抗氧化剂状态和动脉粥样硬化斑块形成的影响。

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摘要

BACKGROUND AND AIM: The results of a number of studies suggest that garlic (or garlic extracts) may have favourable effects against the development of atherosclerosis. The aim of this study was to investigate the effects of garlic extract supplementation on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aortic tissue. METHODS: AND RESULTS: Twenty-two male New Zealand White rabbits were fed a cholesterol-supplemented diet (0.5 g/Kg/day) and nine control rabbits a regular diet for four months. At the end of this period, atherosclerotic plaque formation and antioxidant activity were measured in the aortic tissue of the controls and seven of the cholesterol-fed animals. Of the remaining 15 experimental animals, seven were fed normal laboratory diet and eight a normal diet plus garlic extract (1.5 ml/Kg/day) for a further three months before atherosclerotic plaque formation and antioxidant activity were measured in the aortic tissue of both groups. The cholesterol-fed animals showed a significantly impaired antioxidant system associated with increased plaque formation. However, garlic extract supplementation significantly improved antioxidant status and reduced the plaque surface area. CONCLUSIONS: In this experimental model, garlic extract dietary supplementation activated the antioxidant system and decreased peroxidation in aortic tissue. There was also a reduction in atherosclerotic plaque area. Although further studies are required to elucidate the mechanisms involved, the protective activity of garlic extract may be due to its antioxidant properties.
机译:背景与目的:大量研究结果表明,大蒜(或大蒜提取物)对动脉粥样硬化的发展可能具有有利的作用。这项研究的目的是研究大蒜提取物对家兔主动脉组织中氧化剂/抗氧化剂状态和动脉粥样硬化斑块形成的影响。方法和结果:22只雄性新西兰白兔接受了补充胆固醇的饮食(0.5 g / Kg /天),九只对照兔进行了常规饮食,为期四个月。在此期间结束时,在对照组和7位以胆固醇喂养的动物的主动脉组织中测量了动脉粥样硬化斑块的形成和抗氧化活性。在剩下的15只实验动物中,有7只接受了常规实验室饮食,另外8只接受了常规饮食加大蒜提取物(1.5 ml / Kg /天),持续了三个月,然后在两组的主动脉组织中测量了动脉粥样硬化斑块的形成和抗氧化活性。 。用胆固醇喂养的动物表现出与斑块形成增加有关的抗氧化系统明显受损。但是,大蒜提取物补充剂可显着改善抗氧化剂状态并减少菌斑表面积。结论:在该实验模型中,大蒜提取物膳食补充剂激活了抗氧化系统并降低了主动脉组织中的过氧化。动脉粥样硬化斑块面积也减少。尽管需要进一步研究阐明所涉及的机理,但大蒜提取物的保护活性可能是由于其抗氧化特性。

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