Clinical transplantation of human embryonic neural stem cells for the treatment of cerebral infarction sequelae

摘要

OBJECTIVE: To investigate the effect of embryonic neural stem cell (NSC) transplantation on cerebral infarction sequelae. METHODS: From June 2004 to June 2008, embryonic NSCs were implanted into the ipsilateral basal ganglia region in 21 patients with cerebral infarction, using stereotactic technology. The function independence measure (FIM) was used to evaluate motor function and quality of life in the 21 patients before treatment, and at 1 and 6 months after treatment. FIM was regarded as effective if elevated by ??1 point. RESULTS: Clinical symptoms improved at an effective rate of 80.95% (17/21 cases). The FIM scores were 93.76??6.83 at 1 month after treatment, which was significantly higher than 91.21??6.42 before treatment; however, they were significantly lower than 97.45??7.56 at 6 months after treatment. Patients undergoing embryonic NSC transplantation had no serious complications. CONCLUSIONS: NSC transplantation can improve cerebral infarction sequelae including motor function and living quality in patients to some extent. However, the long-term effect of NSC transplantation still needs further study.