Postsurgical Infection: Comparative Efficacy of Intravenous Cefoperazone/Sulbactam and Cefazoline in Preventing Surgical Site Infection After Neurosurgery

摘要

Surgical site infections (SSIs) are the most common complication for surgically treated patients, resulting in increased rates of morbidity and mortality, length of hospital stay, and cost The average SSI rate without antibiotics ranges between 5% and 11% in cerebrospinal fluid (CSF) shunts, between 1% and 5% in craniotomies or spinal surgeries in clean or clean-contaminated patients, and between 11% and 38% in CSF fistulas.The use of antibiotic prophylaxis in neurosurgery is still controversial; although many centers, including ours, prefer to administer antibiotics to all patients. In randomized, controlled trials antibiotic prophy-laxis has been shown to decrease the rate of SSIs in clean neurosurgical operations. In the United States antibiotic guidelines have been adopted widely.Previous clinical trials have provided no evidence of superiority of one antibiotic to another for prevention of SSIs after clean neurosurgical operations.