Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as inhibitors of microbial quorum sensing

摘要

(E)-and(Z)-5-(Bromomethylene)furan-2(5H)-ones and(E)-and(Z)-3-(bromomethylene)isobenzofuran-1(3H)-ones have been prepared starting from commercially available maleic anhydrides and phthalic anhydrides,respectively.A debrominative decarboxylation or a bromodecarboxylation reaction is a key step in the synthesis.The furanones were investigated for their ability to interfere with microbial communication and biofilm formation by Staphylococcus epidermidis.