In vitro and in vivo degradation evaluation of novel iron-bioceramic composites for bone implant applications

摘要

Biodegradablemetals such asmagnesium, iron and their alloys have been known as potentialmaterials for temporary medical implants. However, most of the studies on biodegradablemetals have been focusing on optimizing their mechanical properties and degradation behavior with no emphasis on improving their bioactivity behavior. We therefore investigated the possibility of improving iron biodegradation rate and bioactivity by incorporating various bioactive bioceramics. The iron-based bioceramic (hydroxyapatite, tricalcium phosphate and biphasic calcium phosphate) composites were prepared by mechanical mixing and sintering process. Degradation studies indicated that the addition of bioceramics lowered the corrosion potential of the composites and slightly increased their corrosion rate compared to that of pure iron. In vitro cytotoxicity results showed an increase of cellular activity when rat smooth muscle cells interacted with the degrading composites compared to pure iron. X-ray radiogram analysis showed a consistent degradation progress with that found in vivo and positive tissue response up to 70 days implantation in sheep animalmodel. Therefore, the iron-based bioceramic composites have the potential to be used for biodegradable bone implant applications.