Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice.

Cheng FC; Ni DR; Wu MC; Kuo JS; Chia LG

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice.

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Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice.

机译：胶质细胞源性神经营养因子可保护C57BL / 6小鼠免受1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的神经毒性。

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To mimic chronic exposure to neurotoxins in inducing dopaminergic cell damage, multiple doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were injected in C57BL/6 mice. Effects of pre- and post-treatment with the glial cell line-derived neurotrophic factor (GDNF) by injections into the striatum were investigated. GDNF exerts protective and reverse effects on the dopaminergic damage, supporting the potential application of GDNF in prevention and treatment of Parkinson's disease.

机译：为了模拟慢性暴露于神经毒素诱导多巴胺能细胞损伤，在C57BL / 6小鼠中注射了多剂量的1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）。研究了神经胶质细胞源性神经营养因子（GDNF）注射到纹状体中前后的作用。 GDNF对多巴胺能损伤具有保护作用和逆作用，支持GDNF在帕金森氏病的预防和治疗中的潜在应用。

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《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |1998年第2期|共4页
作者
Cheng FC; Ni DR; Wu MC; Kuo JS; Chia LG;
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正文语种 eng
中图分类人体生理学;
关键词
Dopamine Agents; Nerve Tissue Proteins; Neuroprotective Agents; Parkinson Disease; Secondary drug therapy; 多巴胺制剂; 神经组织蛋白质类; 神经保护药; 1-甲基-4-苯基-1; 2; 3; 6-四氢吡啶;

机译：Dopamine Agents;Nerve Tissue Proteins;Neuroprotective Agents;Parkinson Disease;Secondary drug therapy;多巴胺制剂;神经组织蛋白质类;神经保护药;1-甲基-4-苯基-1;2;3;6-四氢吡啶;

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1. Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. [J] . Cheng FC, Ni DR, Wu MC, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1998,第2期

机译：胶质细胞源性神经营养因子可保护C57BL / 6小鼠免受1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的神经毒性。
2. Gender differences on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in C57BL/6 mice. [J] . Ookubo M, Yokoyama H, Kato H Molecular and Cellular Endocrinology . 2009,第1a2期

机译：C57BL / 6小鼠MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）神经毒性的性别差异。
3. Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/Bl mice. [J] . Chen LW, Zhang JP, Kwok Yan Shum D, The Journal of Comparative Neurology . 2006,第6期

机译：神经生长因子，neurotrophin-3和胶质细胞源性神经营养因子在1-甲基-4-苯基-1,2,3,6-四氢吡啶处理的C57尾状壳中表达巢蛋白的反应性星形胶质细胞中的定位/ B1小鼠。
4. Neuroprotective Effects of Phenylethanoid Glycosides from Cistanches salsa against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Induced Dopaminergic Toxicity in C57 Mice [C] . Xingchao Geng, Liangwen Song, Xiaoping Pu, Collection of Academic Papers(2004) . -1

机译：肉Ci蓉中的酚类乙醇苷对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的C57小鼠多巴胺能毒性的神经保护作用。
5. I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission. II. New Small-Molecule Inducers of Glial Cell Line-Derived Neurotrophic Factor (GDNF) from C6 Glioma Cells [D] . Karpowicz, Richard James 2013

机译：I.用于单胺转运蛋白活性和突触传递研究的高级荧光假神经递质。二。来自C6胶质瘤细胞的胶质细胞源性神经营养因子（GDNF）的新小分子诱导剂
6. Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity [O] . Bin Xing, Tao Xin, Lingling Zhao, -1

机译：胶质细胞系衍生的神经营养因子保护中脑多巴胺能神经元免受脂多糖神经毒性
7. Protection by Synergistic Effects of Adenovirus-Mediated X-Chromosome-Linked Inhibitor of Apoptosis and Glial Cell Line-Derived Neurotrophic Factor Gene Transfer in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease [O] . Olaf Eberhardt, Rainer V. Coelln, Sebastian Kügler, 2000

机译：通过协同作用的腺瘤介导的X-染色体连接抑制剂凋亡和神经胶质细胞系衍生的神经营养因子基因转移的协同作用在帕金森病的1-甲基-4-苯基-1,2,3,6-四氢吡啶模型中

Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice.

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