Cortical spreading depression during streptozotocin-induced hyperglycaemia in nutritionally normal and early-malnourished rats.

摘要

Cortical spreading depression (SD) was investigated in adult rats during Streptozotocin (STZ)-induced hyperglycaemia (group S; n=13). SD velocities of propagation were significantly lower than in the controls injected only with vehicle solution (group V; n=17). In contrast, rats rendered hypoglycaemic by food restriction+insulin for 3 days (group HG; n=9) presented SD velocities significantly higher than controls; this effect was reversed by injecting glucose during the recording session. SD velocity in early-malnourished rats was not different during STZ-hyperglycaemia (group MS; n=8) compared with previously-malnourished rats injected with vehicle (group MV; n=9). The data indicate an inverse relationship between glycaemia changes and SD propagation in well-nourished rats. Early malnutrition seems to abolish the effect of STZ-hyperglycaemia on SD.