首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.
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Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.

机译:乙酰基左旋肉碱可增强Na(+),K(+)-ATPase谷胱甘肽-S-转移酶和多个单位的活性,并减少老年大鼠脑区域的脂质过氧化作用和脂褐素浓度。

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摘要

This study investigated the effects of chronically administered acetyl-L-carnitine (ALC) on sodium potassium adenosine triphosphatase (Na(+), K(+)-ATPase), glutathione-S-transferase (GST), glutathione peroxidase (GPx), multiple unit activity (MUA) and lipid peroxidation (LP) and lipofuscin (LF) concentration in brain regions: cerebral cortex, hippocampus, striatum and thalamus, of 24-month-old rats. The activity of Na(+), K(+)-ATPase and GST was enhanced; that of GPx was unaffected. The MUA was increased while the levels of LP and LF were decreased. These novel data provide new additional evidence concerning the antiaging attributes of ALC.
机译:这项研究调查了长期服用乙酰左旋肉碱(ALC)对钠钾钠三磷酸腺苷酶(Na(+),K(+)-ATPase),谷胱甘肽S-转移酶(GST),谷胱甘肽过氧化物酶(GPx)的影响, 24个月大大鼠的大脑区域(大脑皮层,海马,纹状体和丘脑)中的多单位活性(MUA)和脂质过氧化(LP)和脂褐素(LF)浓度。 Na(+),K(+)-ATPase和GST的活性增强; GPx的功能不受影响。 MUA增加,而LP和LF水平降低。这些新颖的数据提供了有关ALC的抗衰老特性的新的额外证据。

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