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Nerve growth factor and neurotrophin-3 promote chemotaxis of mouse macrophages in vitro.

机译:神经生长因子和Neurotrophin-3促进体外小鼠巨噬细胞的趋化性。

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摘要

Microchemotaxis chambers were used to explore macrophage chemotaxis in response to the neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Both NGF and NT-3, but not BDNF, promoted macrophage chemotaxis that was receptor mediated and dependent on protein phosphorylation. These in vitro observations point to novel roles for neurotrophins that are present in nerve prior to and immediately after injury.
机译:微趋化室用于研究对神经营养蛋白,神经生长因子(NGF),脑源性神经营养因子(BDNF)和神经营养蛋白3(NT-3)的反应。 NGF和NT-3,但不是BDNF,均能促进巨噬细胞趋化性,该趋化性是受体介导的并依赖于蛋白质的磷酸化。这些体外观察表明,神经营养蛋白在损伤之前和之后立即存在于神经中的新作用。

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