Effects of acute hypoxia on the intensity of free-radical processes in the basal nuclei of the brain and behavior in rats in the open field test in conditions of an altered photoperiod

摘要

The effects of acute hypoxia on the intensity of free-radical processes in the basal nuclei(caudate nucleus, globus pallidus, nucleus accumbens, amygdalar complex) and the behavior of rats in an open field were studied in conditions of an altered photoperiod. Constant darkness was found to eliminate the effects of acute hypoxia on the intensity of lipid peroxidation(LPO), to preserve superoxide dismutase and catalase activities at higher levels, and to decrease glutathione peroxidase activity. In the light, there were increases in the sensitivity of neurons in the basal nuclei to acute hypoxia, which was manifest as intensification of LPO due to increased formation of diene conjugates. Catalase activity in almost all structures was significantly greater even than in intact rats. Altered photoperiods were found to modulate the effects of acute hypoxia on measures of activity in rats in the open field, the nature of the changes depending on the nature of the change in photophases.