Cortical action myoclonus due to cortical laminar necrosis

摘要

Cortical myoclonus is the most common form of myoclonus, mainly affecting distal upper limbs and typically occurring during voluntary action [1]; in particular, focal cortical myoclonus is frequently caused by a focal lesion affecting excitability of the sensorimotor cortex [1]. Transcranial magnetic stimulation (TMS) evaluates the excitability state of the primary motor cortex [2], representing an important tool to study focal cortical myoclonus [3]. Cortical laminar necrosis (CLN) is defined as hyperintense cortical lesion on Magnetic Resonance Imaging (MRI) T1-weighted sequences involving specific cortical laminae observed after a subacute or chronic brain damage [4]. We here present a patient with cortical action myoclonus associated with CLN.