Gold(I)-catalyzed heterocyclization of beta-alkynyl hydroxamic acids: synthesis of isoxazolidin-3-ones

摘要

A practical and mild method for the 5-exo cyclization of N-substituted alpha-alkynyl hydroxamic acids into isoxazolidin-3-ones catalyzed by Au(PPh3)SbF6 was developed. Under optimized conditions, the cyclization shows a highZ-selectivity for the newly formed exocyclic double bond.