Thiol derivatives of arylnaphthylmethane as novel anti-osteoporotic agents

摘要

(Mercaptophenyl)naphthylmethane derivatives were synthesized as novel estrogen receptor binding ligands.[4-(Methylsulfonyl)phenyl](naphth-1-yl)ketone shows a very promising activity towards osteoporosis.Type II osteoporosis is a common disease associated with old age.In females,it has been linked to postmenopausal decrease of estrogen level[1].In an approach towards development of anti-osteoporotic agents,a large number of non-steroidal estrogens/anti-estrogens have been studied for estrogen replacement therapy.