3,4-(Methylenedioxy)aniline as precursor to the synthesis of thiazolidin-4-ones

摘要

New 2-aryl-3-(benzo[d][1,3]dioxol-5-yl)thiazolidin-4-ones were easily synthesized by one-pot reaction of (3,4-methylenedioxy)aniline, arenaldehydes (or cyclohexanone), and mercaptoacetic acid which results in good yields. The thiazolidinones were fully identified and characterized by spectroscopic techniques as H-1 and C-13 NMR, mass and high resolution mass. These novel heterocycles are potential biological compounds due the presence of both important moieties: thiazolidinone and 1,3-benzodioxole.