Preparation and characterization of iminodiacetic acid: magnetite nano-particles as a novel famotidine carrier substrate for sustained drug release

摘要

In this paper, a new method is reported for the surface immobilization of magnetic nano-particles modified by iminodiacetic acid. The immobilized nano-sorbent was characterized by Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis, and transmission electron microscopy. Agglomerated magnetic nano-particles were used for sorption of famotidine in simulated intestinal and gastric fluids. The profile of the famotidine uptake by nano-sorbent reflected the high accessibility of the active sites in the immobilized sorbent. The equilibrium adsorption data of famotidine by nano-sorbent were analyzed by Langmuir, Freundlich, Temkin, and Redlich-Peterson isotherm models. The sorption capacity was 15.2 mg g(-1) at optimum pH of 5. Nearly 86 % of famotidine was released in simulated gastric fluid, pH = 1.2, in 60 min and 60 % in simulated intestinal fluid, pH = 7.4, in 30 h. These results indicate the efficiency of the famotidine loaded onto immobilized magnetic nano-sorbent for targeted drug delivery.