Synthesis of 6-methyl-8H-dibenzo[a,g]quinolizin-8-imines via Reissert compounds

摘要

Alkylation of Reissert compounds derived from 3-methylisoquinolines with several 2-cyanoben-zylbromides followed by hydrolytic cleavage provided the corresponding l-benzyl-3-methylisoquinolines.Treatment of the latter with methylmagnesiumiodide caused cyclization to the title compounds rather than formation of 2-acetylbenzylisoquinolines.