REISSERT COMPOUNDS AS ANTI-HIV AGENTS

摘要

The invention relates to heterocyclic compounds represented by formula (I) which are used to treat AIDS and AIDS related conditions. These compounds are generally synthesized following the reactions and the conditions used for producing the Reissert compounds. The compounds of the formula (I) are 1,2-dihydroquinolines, 1,4-dihydroquinolines, 1,2,3,4-tetrahydroquinolines, 1,2-dihydroquinazolines and 1,2-dihydroquinoxalines. Type compounds are 1- (4-bromobenzoyl) -2-cyano-1,2-dihydroquinoline, 1- (4-chlorobenzoyl) -2-cyano-5-fluoro-1,2-dihydroquinoline, 1- (4-chlorobenzoyl ) -2-cyano-6-fluoro-1,4-dihydroquinoline, 1- (4-chlorobenzoyl) -2-cyano-1,2,3,4-tetrahydroquinoline, 1- (4-chlorobenzoyl) -2-carboximidamide- 8-fluoro-1,2-dihydroxyquinoline, 1- (4-chlorobenzoyl) -2-cyano-1,4-dihydroquinoxaline, 1-E- (3- (4-chlorophenyl) -1-oxo-2-propenyl) - 2-cyano-1,2-dihydroquinoline and 1-E- (3- (4-chlorophenyl) -1-oxo-2-propenyl) -2-carboximidamide-1,2-dihydroquinoline. The invention also discloses a method of treating AIDS or AIDS-related conditions with an effective amount of one of these compounds.