From Reverse to Forward Chemical Genomics: Development of Anti-HIV Agents

摘要

To date, several anti-HIV agents have been developed based on reverse chemical genomics, in which target molecules are fixed. We found that CD4 mimic compounds have a great effect on the dynamic supramolecular mechanism of HIV entry, and that their combinational use with CXCR4 antagonists or with neutralizing antibodies shows a synergistic effect. On the other hand, based on forward chemical genomics, in which active compounds are searched according to the screening of random libraries, effective leads such as integrase inhibitors and matrix peptides have been found.