DIVERGENT TOTAL SYNTHESIS OF AZALAMELLARINS D AND N

摘要

Lamellarins are polycyclic marine alkaloids with potent cytotoxic activities against cancer cell lines.A divergent synthesis of azalamellarins D and N,lactam congeners of the marine natural products lamellarins D and N,has been achieved via the pentacyclic 14-bromo-8,9-dihydrobenzo7,8indolizino3,2-c-quinolin-6(5H)-one intermediate.The pentacyclic intermediate can be synthesized from methyl l-(benzensulfonyl)-3-bromo-lH-pyrrole-2-carboxylate via the Suzuki-Miyaura cross-coupling and intramolecular direct arylation as key reactions.