Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound

摘要

Polyhydroxy enyne compound (+)-(1′S, 2R, 3S, 5S, 6S)-5,6-dimethoxy-5, 6-dimethyl- 2-(1’-hydroxylpropyl-2-ne)-3-vinyl-1,4-dioxane has been synthesized from D-(-)-tartaric acid. A new chiral center was established by nucleophilic addition with 87% de. The modified Mosher’s method was employed to confirm the absolute configuration of 17, which assigned the S-configuration at the new chiral center.